The Week 16 edition of "Monday Night Football" between the Indianapolis Colts (8-7) and the San Francisco 49ers (11-4) will be remembered as the Brock Purdy game. The 49ers quarterback powered San Francisco to a 48-27 road victory with a career-high five passing touchdowns.

Briana Jeannel looks back on San Francisco's Bye week, and Amie Wells joins The Saloon to break down the Week 15 matchup vs. the Tennessee Titans, with sounds from CB Renardo Green, WR Jauan Jennings,

The Los Angeles Rams lost a heartbreaker to the Seattle Seahawks on Thursday night, blowing a 16-point fourth-quarter lead and losing in overtime, 38-37. It was as painful a loss as they've suffered this season, dropping to 11-4 and relinquishing their lead in the NFC West, as well as giving up control of the No. 1 seed.

Philip Rivers starts again when he takes on the ferocious 49ers on "Monday Night Football." Here's score, highlights, stats and more for Colts-49ers.

JJ Stankevitz from the Indianapolis Colts previews Week 16 "Monday Night Football", with one-on-one interviews featuring San Francisco 49ers DL Clelin Ferrell and WR Jauan Jennings.

The San Francisco 49ers have beaten the Indianapolis Colts 48-27 on “Monday Night Football” behind Brock Purdy ’s career-high five touchdown passes. Christian McCaffrey racked up 146 total scrimmage yards and caught two touchdowns, while George Kittle totaled seven receptions for 115 yards and a TD before leaving the game with an ankle injury.

Indianapolis Colts quarterback Philip Rivers says he is enjoying his return to the NFL even after losing his first two starts in almost five years.