Phys.org

Iron catalyst drives asymmetric 1,6 addition of aliphatic Grignard reagents to α,β,γ,δ-unsaturated carbonyl compounds

Scientists at the Institute of Science Tokyo (Science Tokyo) have successfully realized the highly selective asymmetric 1,6 addition of aliphatic Grignard reagents to α,β,γ,δ-unsaturated carbonyl ...
Nature

Reaction for coupling 3D molecular fragments expands the chemist’s toolkit

Finding a life-changing drug molecule is like playing the lottery — only one out of several million candidate organic molecules that are initially screened might progress through preclinical studies ...
EurekAlert!

Highly selective asymmetric 1,6-addition of aliphatic Grignard reagents to α,β,γ,δ-unsaturated carbonyl compounds

The reaction utilizes an iron catalyst together with an N-heterocyclic carbene (NHC) ligand, which suppresses unwanted side reactions to promote highly selective nucleophile addition. In organic ...