A flurry of recent studies implicating microglia as key players in neurodegenerative diseases, particularly Alzheimer’s, has cued many labs to try to figure out how these cells function in health, and ...

When the results are analyzed in terms of relative risk, as done by Farrer and colleagues, [4] the APOE4 allele was found associated with an increased risk of AD, whereas the E2 allele appeared to ...

"These data support the hypothesis that a primary mechanism for apoE-mediated plaque formation may be a result of apoE aggregation, as preferentially targeting of apoE aggregates with therapeutic ...

The APOE ε4 allele was linked to clinical expression and biomarkers of Alzheimer's disease in people with Down syndrome, a dual-center cohort study showed. Among 464 adults with Down syndrome, APOE ε4 ...

A new study, published today in Nature Communications, offers clues into how APOE isoforms differentially affect human microglia function in Alzheimer's disease. The study, led by Dr. Sarah Marzi and ...

A new research paper was published in Aging (Aging-US) Volume 17, Issue 5, on May 3, 2025, titled "APOE genotype and biological age impact inter-omic associations related to bioenergetics." In this ...

A recent study published in Alzheimer’s Research & Therapy examined the long-term subjective cognitive decline risk associated with Herpes zoster infections. It investigated whether the association ...

Researchers at Yale School of Medicine (YSM) examined two known risk factors for developing dementia—one genetic and one ...

People who regularly ate higher-fat cheese and cream had a lower risk of dementia over 25 years, while low-fat dairy and ...