How many ways can a troponin assay come up with a false positive or a false negative? In this episode of AP Cardiology, Andrew Perry, MD, tallies it up with Robert Christenson, PhD, of the University ...

Bilirubin interference in the widely used Jaffe creatinine assay led to artificially elevated Model for End-Stage Liver Disease (MELD) scores in a substantial proportion of patients with end-stage ...

You run the assay. The values come back off. Not catastrophically wrong, just inconsistent enough to make you doubt everything. You've checked the protocol twice. The kit hasn't expired. But the CV is ...

Avoiding immunoassay interference requires blockers to be included in every immunoassay. Historically, animal-based interference blockers have been used to improve assay accuracy; however, they are ...

Interference in laboratory assays is a concern since it can positively or negatively influence test results, which can affect patient care. Interferents could be endogenous or exogenous compounds.

Immunoassays used for human in vitro diagnostics (IVD) often use animal-sourced antibodies to recognize specific disease markers. A small percentage of individuals, however, may have antibodies in ...

Luminescence and fluorescence-based assay methods prevail in modern HTS. Although invaluable as technologies, the problem of compound-related assay interferences such as quenching, auto-fluorescence, ...

Increasingly accessible to academic researchers, high-throughput screening (HTS) is one of the best ways to discover starting points for new chemical probes and first-in-class drug candidates. However ...