Nature

Expression of carbonic anhydrase 9, a potential intrinsic marker of hypoxia, is associated with poor prognosis in oesophageal squamous cell carcinoma

Oesophageal cancer is a common malignant neoplasm throughout the world. Despite recent improvements in surgical techniques, chemotherapy and radiation treatment, the prognosis for patients with ...
ascopubs.org

Elevated pretreatment serum CA9 (carbonic anhydrase 9) and correlation with progression-free and overall survival in trastuzumab-treated metastatic breast cancer.

Association between endoxifen serum concentration and predicted CYP2D6 phenotype in a prospective cohort of patients with early-stage breast cancer. Background: Approximately one-half of HER2-positive ...
ascopubs.org

Endogenous Markers of Two Separate Hypoxia Response Pathways (hypoxia inducible factor 2 alpha and carbonic anhydrase 9) Are Associated With Radiotherapy Failure in Head and ...

Randomized controlled trials have generally shown a benefit from accelerated radiotherapy in head and neck squamous cell carcinoma (HNSCC). However, the large randomized United Kingdom trial CHART ...
BioWorld

Theranostic agent for CA9-expressing tumors presented

Carbonic anhydrase IX (CAIX, CA9) is a membrane-associated isoform of the α-carbonic anhydrase enzyme family, involved in pH regulation and the acidification of the tumor microenvironment (TME) in ...
The New England Journal of Medicine

Blood Carbonic Anhydrase Activity and Zinc Concentration in Infants with Respiratory-Distress Syndrome

CARBONIC anhydrase is a zinc metalloenzyme that reversibly catalyzes the hydration of carbon dioxide to bicarbonate and hydrogen ions according to the following equation 1: Blood was obtained from ...