Figure 1: KMAP visualisation of SELEX-seq data for the transcription factor MAFK. Each dot represents a k-mer. Clusters of k-mers at the center correspond to DNA motifs, while the surrounding dots ...
When AlphaFold solved the protein-folding problem in 2020, it showed that artificial intelligence could crack one of biology’s deepest mysteries: how a string of amino acids folds itself into a ...
Therapeutic landscape of Rad51 in cancer treatment. Key elements include (1) DNA damage sources (PARPi, chemo/radiotherapy);(2) repair pathways (Rad51‐mediated HR); (3) intervention strategies (Rad51 ...
DNA and RNA methylation, initially thought to operate as distinct pathways, have been shown to interact closely, shifting our understanding of gene regulation. A team of researchers from the ...
Every cell type in the human body carries the same approximately 3.2 billion base pairs of DNA, yet a liver cell behaves nothing like a neuron. The epigenome explains this difference: in each cell, ...
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Cracking the code of gene regulation
From DNA’s tightly packed chromatin to the precise on/off switches in regulatory sequences, scientists are uncovering how cells fine-tune gene expression. New research reveals surprising roles for ...
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