Randomized trials of platelet function and genetic testing to guide antiplatelet decisions following PCI have produced notoriously mixed results: now, an updated consensus document aims to fill some ...

Mesenchymal stem cells are both a success story and underperformers. Globally, there are 10 approved MSC-based therapies in nearly as many indications, although none of them have been approved by the ...

Monocytes, a special type of white blood cell, secrete cytokines as inflammatory messengers that are crucial for an appropriate immune response. Researchers at the University Hospital Bonn (UKB) and ...

In a recent study published in the Journal of Thrombosis and Haemostasis, researchers investigated the role of platelets in the adverse immune response against a coronavirus disease 2019 (COVID-19) ...

Managing drug dosage is critical to the overall success of pharmaceutical intervention, not only in the clinic but also in clinical trials. Inadequate dose management of certain drugs can have fatal ...

Intravital microscopy image from the liver of a mouse model: a platelet (turquoise) adheres to the inflamed vessel wall (yellow dashed outline) and sheds a long, filamentous membrane extension—a ...

Ado-trastuzumab emtansine (T-DM1) treatment results in grade 3-4 thrombocytopenia in 8%-13% of patients. Prior in vitro studies reported T-DM1 inhibition of megakaryocyte maturation as the cause of ...

The lives of many cancer patients are saved by the transfusion of platelets, but there is a chronic shortage of these fragile blood-clotting components because of spoilage. A new technique may double ...

Essential thrombocythemia (ET) is a type of myeloproliferative neoplasm (MPN), a rare blood disorder that causes an increase in the number of blood cells. Some symptoms include headaches, dizziness, ...