As the first clinical trial of the drug novobiocin is about to open for patients with cancers carrying BRCA gene mutations, new research at Dana-Farber Cancer Institute shows the drug poses a double ...
Elevated serum c-erbB-2 antigen levels and decreased response to hormone therapy of breast cancer. Resistance to alkylators may potentially be overcome by drugs that inhibits DNA repair, thus ...
This study explored the resistance mechanisms of Staphylococcus aureus (S. aureus) to novobiocin, a gyrB inhibitor. Through adaptive laboratory evolution, key resistance mutations (in gyrB, potB, and ...
Novobiocin and coumermycin are known to inhibit the replication of DNA in Escherichia coli. We show that these drugs inhibit the supercoiling of DNA catalyzed by E. coli DNA gyrase, a recently ...
THE clinical use of novobiocin is increasing because of its effectiveness in the treatment of staphylococcal infections. Toxic reactions 1, 2 include mild diarrhea (37 per cent), skin rashes (8.9 per ...
BOSTON - An antibiotic developed in the 1950s and largely supplanted by newer drugs, effectively targets and kills cancer cells with a common genetic defect, laboratory research by Dana-Farber Cancer ...
A SIX-year-old girl was seen at the United States Army Hospital, Fort Rucker, Alabama, with a chief complaint of mild jaundice and dark urine present for one day. The child had previously been seen by ...
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