Naloxone, also known by the brand name Narcan, is one of the most important drugs in the United States' fight against the opioid crisis. It reverses an opioid overdose nearly instantly, restarting ...

Drugs that target opioid receptors sometimes have severe side effects. Thousands of people around the world die every day from overdoses involving opioids such as fentanyl. Researchers have taken a ...

The researchers captured eight unique structural models and 16 cryogenic electron microscopy maps of the receptor with both ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 16 (April 19, 2022), pp. 1-10 (10 pages) Allosteric modulators of G-protein-coupled receptors (GPCRs) ...

Drugs that target opioid receptors sometimes have severe side effects. Thousands of people around the world die every day from overdoses involving opioids such as fentanyl. An international team of ...

Scientists have visualized for the first time how opioids such as loperamide and the antidote naloxone engage a key brain receptor, offering insight that could lead to better pain treatments.

Listening to a favorite song can trigger a profound emotional response that rivals the feelings produced by biological ...

Researchers have observed that the length of daylight hours impacts opioid receptor levels in brown fat. When daylight hours shorten, the receptor activity levels elevate. A similar phenomenon also ...

When the season turns darker and colder, animals’ brown fat starts to grow. The tissue produces heat efficiently and rapidly, and regulates appetite. Brown fat is also present in people. In a new ...