Understanding the delicate balance between nucleophilicity and electrophilicity is fundamental to rationalising reaction mechanisms in organic chemistry. Nucleophilic reactivity describes a molecule’s ...

As a footnote to Mark M. Green’s letter on how to make organic chemistry “be part of understanding the wider world, to be worth knowing” (Jan. 2, 2023, page 3), I wish to illustrate my approach to “a ...

Highly reactive organometallic reagents, like organolithiums (molecules with a carbon–lithium bond) are essential reagents in organic synthesis because of their applications from polymer synthesis to ...

This module teaches fundamentals of pericyclic reactions using examples of biocatalysis, biomimetic catalysis, and natural product total synthesis. After completion, students should be able to ...

Organic chemist Bruce Lipshutz had a bit of a rude awakening. It was around 2007, and the head of environmental health and safety (EH&S) at the University of California, Santa Barbara, sat Lipshutz ...