KAE609 (cipargamin; formerly NITD609, Novartis Institute for Tropical Diseases) is a new synthetic antimalarial spiroindolone analogue with potent, dose-dependent antimalarial activity against asexual ...
Although the clinical efficacy of antimalarial artemisinin-based combination therapies in Africa remains high, the recent emergence of partial resistance to artemisinin in Plasmodium falciparum on the ...
New research synthesizes information from many different studies that attempt to link specific antibody responses to Plasmodium falciparum with protection from clinical malaria and comes to important ...
The evolutionary path of the deadliest human malaria parasite, Plasmodium falciparum, has been revealed for the first time. This parasite is a member of the Laverania parasite family that only infect ...
To gain insight into why antibody responses to malarial antigens tend to be short lived, we studied antigen-specific memory B cells from donors in an area where malaria is endemic. We compared ...
Calcium is essential for the correct functioning of the cell and requires regulation to avoid high concentrations causing cell death. Calcium ions are important for cell signaling as the binding of ...
Engineered Plasmodium parasites form the basis of two experimental malaria vaccines that showed safety and encouraging immune responses in clinical trials. Two studies show that Plasmodium—the genus ...
Immune modulation of Plasmodium vivax and P. falciparum gametocytes occurs over the course of erythrocytic infection. The response is linked to proliferative and inflammatory responses, which may be ...
Thought LeadersProfessor Karine Le RochDirector of the Center for Infectious Disease and Vector ResearchUniversity of California, Riverside As part of World Malaria Day 2022, we interview Karine Le ...
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