A mysterious neurological disease was killing women and children in the Eastern Highlands of Papua New Guinea. Patients in the final stages experienced uncontrollable outbursts of laughter, earning ...

In a new study, researchers from the Case Western Reserve University School of Medicine have identified the structure of protein fibrils linked to a hereditary form of human prion disease. This ...

UCSF scientists have demonstrated for the first time that a change in the folded shape of a prion protein changes its infectious properties—including the prion’s ability to jump “species barriers.” ...

Glioblastoma (GBM), one of the most aggressive types of brain cancer, is one of the greatest challenges for medicine, both because it is difficult to treat and because of its high mortality rate. In ...

A new study with transgenic mice provides the first concrete evidence that a disease-associated prion protein mutation in an otherwise normal mammalian brain can generate a unique self-perpetuating ...

The prion protein forms functional condensates that are enriched at cell-cell interfaces. However, long exposure to copper ions/hydrogen peroxide that result in oxidative stress, triggers a ...

Genetic prion disease generally manifests with cognitive difficulties, poor muscle control and abrupt jerking movements of muscle groups and/or entire limbs. The three major phenotypes of genetic ...

Yeast prions are increasingly recognised as pivotal agents in non-Mendelian inheritance, whereby protein conformations rather than nucleic acids dictate heritable traits. In Saccharomyces cerevisiae ...

In a new study, researchers from Case Western Reserve University School of Medicine have identified the structure of protein fibrils linked to a hereditary form of human prion disease. This insight, ...