In a recent study under review at the Scientific Reports journal and currently posted to the Research Square* preprint server, researchers synthesized and evaluated the antitumoral (against several ...

Spirocyclic compounds, characterised by two or more rings sharing a single quaternary carbon centre, have emerged as pivotal scaffolds in drug discovery and natural product synthesis. Their rigid ...

Spirocyclic architectures have emerged as privileged scaffolds in contemporary medicinal chemistry, offering unique three-dimensional shapes that enhance target engagement, improve pharmacokinetic ...

However, only a few spiro-containing compounds have become representative pesticides on the market at present, such as spirodiclofen and spirotetramat by Bayer. "The reasons include the difficulty of ...

A new reagent has moved carbon-atom transfer out of the chemical flatlands, allowing chemists to place a single carbon atom so that it makes bonds to four different substituents. The reagent makes ...

However, only a few spiro-containing compounds have become representative pesticides on the market at present, such as spirodiclofen and spirotetramat by Bayer. ‘The reasons include the difficulty of ...