Your body is an incredible machine with countless parts working together to keep you healthy. While you’re probably familiar with the superstars — heart, lungs, brain — there’s an underappreciated ...

Changing just one atom in a COVID-19 vaccine lipid redirects delivery from the liver to the spleen, improving tumor ...

The dog spleen is an important organ located in the abdomen. Spleens are so important that almost every species of vertebrate animal has one and some species have multiples. Depending on the species, ...

A preclinical study has analyzed the interactions of the lipid mediator sphingosine-1-phosphate (S1P) in the spleen and heart during the transition from acute to chronic heart failure. Using a mouse ...

Immune protection fades with time, and much of that decline traces back to the thymus. This small organ, located in front of the heart, trains new T cells and releases signals that help them survive.

The human body is an amazing thing. For each one of us, it’s the most intimate object we know. And yet most of us don’t know enough about it: its features, functions, quirks, and mysteries. Our series ...

A single signaling pathway controls whether immune cells attack or befriend cells they encounter while patrolling our bodies, ...

Autoimmune lymphoproliferative syndrome (ALPS) is a rare genetic disorder that can cause chronic swelling of the lymph nodes, spleen, and liver. In addition to causing swelling, ALPS can result in low ...

By manipulating this pathway, scientists may be able to tweak the immune response to treat cancers, autoimmune disorders, and more.