A major aim in biology is to determine how genes give rise to phenotypes. Associating genes and transcripts with phenotypes is easiest for single amino-acid polymorphisms in structural proteins or ...
Treating acute myeloid leukemia (AML) depends on knowing what goes wrong inside cells. A new study suggests that two genetic ...
New research provides a mechanistic map of how genetic mutations disrupt RNA splicing in acute myeloid leukemia.
Spliceosomal snRNAs are transcribed from specialized promoters, which recruit RNA polymerase II cofactors that aid in proper 3′ end maturation of these non-polyadenylated transcripts. Like most ...
Our cells have to generate a massive number of proteins, and there is a carefully orchestrated procedure for doing so. It starts when active genes are transcribed into RNA, and while that RNA ...
Imagine sitting down to watch a film for a second time, but the story takes a surprising turn, for example a new scene or a particular voiceover. You might realize ...
CAMBRIDGE, Mass.--(BUSINESS WIRE)--H3 Biomedicine Inc., a clinical stage biopharmaceutical company specializing in the discovery and development of precision medicines for oncology and a member of ...
The structure of a key enzyme involved in protein production is revealed by cryo-electron microscopy (cryo-EM). Using cryo-EM, researchers at Goethe University (Frankfurt, Germany) shed light on ...
A $1.6million grant from the National Institute of Health (MD, USA) has been awarded to study the underlying biochemistry and crystallography of RNA splicing using bacteria from hot springs. Roughly ...
AZoLifeSciences on MSN
Dual genetic mutations drive RNA mis-splicing and leukemia progression
Treating acute myeloid leukemia (AML) depends on knowing what goes wrong inside cells. A new study suggests that two genetic ...
Some results have been hidden because they may be inaccessible to you
Show inaccessible results
Feedback