Peripheral T cell lymphomas (PTCLs) are a diverse group of aggressive malignancies that arise from mature, post-thymic T cells. Recent genomic and mechanistic studies reveal that these cancers ...
Massachusetts Institute of Technology and Massachusetts General Hospital researchers have developed a messenger RNA vaccine ...
Adoptive T cell therapies for cancer using T cells engineered with chimeric antigen receptors (CAR-T cells) are at the forefront of clinically applied synthetic immunology 1,2,3. Direct cytotoxic ...
We owe a lot to tissue resident memory T cells (T RM). These specialized immune cells are among the body's first responders to disease. Rather than coursing through the bloodstream-as many T cells ...
Cancer-fighting T cells do not simply "run out of energy." They are molecularly reprogrammed. For years, mitochondrial dysfunction has been recognized as a hallmark of exhausted T cells in tumors. Yet ...
Researchers at Texas A&M Health and collaborators have developed engineered CRAC channel inhibitory binders that can ...
Chimeric antigen receptor (CAR) T cell-based therapy has greatly improved cancer treatment, especially for hematologic cancers. 1 By providing T cells with synthetic receptors that target tumor ...
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How developing immune cells fine-tune their signals
Researchers at VIB, Ghent University, and VUB have uncovered how two proteins essential for immune cell development work together at the molecular level. The findings provide important insights into a ...
Introduction Sjögren’s disease (SjD) is a systemic, rheumatic autoimmune disorder evidenced by broad organ-specific ...
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