The tide of the blood coagulation cascade turns by a switch in thrombin specificity. Two new structures reveal how thrombomodulin's EGF domains flip the switch by blocking old substrates and docking ...

Under homeostatic conditions, the body is maintained in a finely tuned balance of coagulation and fibrinolysis. See Figure 1 for a depiction of normal hemostasis. The activation of the coagulation ...

To understand the pharmacology and mechanism of action of ximelagatran, a review of the formation and function of thrombin is warranted. [10] The generation of thrombin is limited under normal ...

Blood coagulation is a balancing act. Too much clotting can lead to strokes. But not enough clotting can lead to uncontrolled bleeding. That balance is particularly important for patients with ...

STOCKHOLM, Sweden – An experimental agent that prevents the formation of blood clots earlier in the coagulation process than other agents has cleared its first hurdle in becoming a potential new ...

The glycoprotein V of the blood platelets is an important switch point for haemostasis and thrombus formation. This new finding could have great clinical potential. When our blood vessels are injured ...

Health-Related Quality of Life in Non–Small-Cell Lung Cancer: An Update of a Systematic Review on Methodologic Issues in Randomized Controlled Trials Recent clinical research has focused on the ...

This is a preview. Log in through your library . Abstract In this study, we tested the hypothesis that factor XI (FXI) activation occurs in plasma following activation of the extrinsic pathway by ...

Fibrin plays a major role in stopping bleeding and healing wounds. However, if fibrin is formed in excess, e.g., in chronic wounds, thrombosis and subsequent vascular occlusions can occur. Therefore, ...

Charlottesville, VA (March 6, 2012). Clinicians from the University of Utah report the death of a patient who received a mild brain injury from a ground-level fall while taking the new anticoagulant ...