Ultraviolet (UV) irradiation is a major mutagenic environmental agent, causing the appearance of DNA adducts that, if unrepaired, may give rise to mutations. Ultraviolet radiation has been indicated ...

CD20-immunotargeting of malignant melanoma. Background: Inability to repair ultraviolet light (UV)-induced DNA damage causes skin cancer. Chloroquine has been shown to activate the DNA damage response ...

In the double helix structure of DNA, thymine forms a base pair with adenine through two hydrogen bonds. This specific pairing is known as complementary base pairing and is essential for the stability ...

Researchers describe for the first time how one type of RNA polymerase gets stalled by DNA lesions caused by exposure to ultraviolet (UV) light. Damage to DNA is a constant threat to cellular life, ...

When the Nobel Prize in Chemistry was awarded last month to Tomas Lindahl, Paul Modrich, and Aziz Sancar for their “mechanistic studies of DNA repair,” the usual mix of congratulatory messages and “oh ...

Thymine, which is often abbreviated as T or Thy, can also be referred to as 5-methyluracil. Thymine is one of the pyrimidine bases found in the nucleic acid of deoxyribonucleic acid (DNA), along with ...

This is a preview. Log in through your library . Abstract The proximity of repair patches to persistent pyrimidine dimers in normal human cells and xeroderma pigmentosum group C and D cells was ...

Experiments were performed to test whether significant amounts of pyrimidine dimers are produced in cultured cells of tobacco (Nicotiana tabacum L. var. Xanthi) and of Haplopappus gracilis by ...