DNA's double helix has long stood as the symbol of life’s code. But buried within the genome lies a deeper level of complexity. One of the more intriguing discoveries in recent years is the i-motif—a ...

Researchers have developed a comprehensive atlas that maps DNA methylation—a critical chemical modification governing gene activity—across 39 human cell types, revealing a complex landscape of ...

An illustration of multicolored tangle of threads within a small black sphere. A 3D illustration shows DNA packaged into the nucleus, scientists with the 4D Nucleome project are now building accurate ...

Innovative study of DNA's hidden structures may open up new approaches for treatment and diagnosis of diseases, including cancer. DNA is well-known for its double helix shape. But the human genome ...

Standard laboratory tests can fail to detect many disease-causing DNA changes. Now, a novel 3D chromosome mapping method can reliably reveal these hidden structural variants and lead to new ...

DNA methylation is an epigenetic modification crucial to normal development, with its dysregulation leading to various diseases including cancer. As interest in epigenomics grows, an innovative ...

In a first-of-its-kind pursuit, scientists have mapped the human genome in four dimensions (4D), according to a study published in the journal Nature. The project is named "4D Nucleome Project." It ...

Standard laboratory tests can fail to detect many disease-causing DNA changes. Now, a novel 3D chromosome mapping method can reliably reveal these hidden structural variants and lead to new ...

Over the past two decades, researchers have learned that DNA inside the cell nucleus naturally folds into a network of ...

Biological processes associated with genes linked to promoter–enhancer pairs in normal and cancerous tissues: brain (D), breast (E), and pancreas (F). Each row represents a group of genes sharing a ...