Salt-inducible kinase 2 (SIK2) is a serine/threonine kinase that regulates transcriptional programs in myeloid cells by phosphorylating transcriptional coregulators. In macrophages, SIK2 promotes the ...

Fulminant colitis is a somewhat rare but serious form of ulcerative colitis (UC). UC causes inflammation and sores in the lining of the colon. It doesn’t happen to most people who have UC. Less than ...

Merck & Co Inc. MRK on Monday said its investigational therapy tulisokibart achieved the primary endpoint in a Phase 3 study in moderately to severely active ulcerative colitis (UC), marking what the ...

Unfortunately the cause of ulcerative colitis is unknown, although both genetic and the environmental causes have been proposed. Most patients with ulcerative colitis do not have anyone else in the ...

Ulcerative colitis is a condition that affects your colon and rectum. Its symptoms vary based on how severe it is. They can range from mild cases with a few stomach cramps and constipation, to more ...

If you have ulcerative colitis, it’s important to seek treatment right away. Delaying treatment — or even downplaying your symptoms to your doctor — could turn a mild case into something much more ...

Although there is no cure for ulcerative colitis, various treatments like medications, surgery, and home remedies can help manage symptoms and extend the time between flare-ups. Newer treatments, ...