Scientists have transplanted a nearly entire human chromosome in mice in a medical and technical breakthrough that could reveal new insights into Down syndrome and other disorders. The genetically ...

Three copies of chromosome 21 causes Down syndrome (DS), and roughly half of children born each year in the United States with DS-approximately 2,600-also have congenital heart defects (CHDs). What is ...

The unveiling of the DNA sequences of human chromosomes represents a new chapter in the unfolding story of genomics, but one with roots in the half-century-old field of cytogenetics. Chromosome-level ...

How does the CRISPR Down Syndrome breakthrough work to remove the extra chromosome 21? We are closer than ever to a world where a genetic condition affecting one in every 700 babies could be addressed ...

Conservation of genomic sequences between species indicates regions of functional importance, containing protein-coding gene, non-coding genes or regulatory elements. In the December 5 Nature, ...

People with a third copy of chromosome 21, known as trisomy 21, are at high risk of developing acute myeloid leukemia (AML), an aggressive form of blood cancer. Scientists have now identified the ...

Three copies of chromosome 21 cause Down syndrome (DS), and roughly half of children born each year in the United States with DS—approximately 2,600—also have congenital heart defects (CHDs). What is ...

For Ashley Zambelli, a surprise diagnosis allowed her to have an even more special bond with her children. The Michigan-based mom, 23, recently found out she has Mosaic Down syndrome, a condition in ...