Cell therapy developer Celyad Oncology is using short-hairpin RNA (shRNA) to create T cells that can be used as an “off-the-shelf” allogeneic therapy for cancer patients. They are also using the ...

RNA-based therapies are enjoying a renaissance, owing in part to the recent approvals of Alnylam Pharmaceuticals’ RNA interference (RNAi) drugs, Onpattro ® (patisiran) and Givlaari™ (givosiran).

The identification of the cellular targets of small molecules with anticancer activity is crucial to their further development as drug candidates. Here, we present the application of a large-scale RNA ...

Short hairpin sequences are encoded within a DNA vector and then introduced inside cells using plasmid transfection or viral transduction. The short hairpin RNA may either be in the firm of simple ...

Loss-of-function phenotypes often hold the key to understanding the connections and biological functions of biochemical pathways. We and others previously constructed libraries of short hairpin RNAs ...

Evaluating the reversible control of an engineered CAR T cell ON-switch. This is an ASCO Meeting Abstract from the 2017 ASCO Annual Meeting I. This abstract does not include a full text component.

A powerful algorithm that improves the effectiveness of an important research technology harnessing RNA interference, or RNAi, has been developed by scientists. Scientists at Cold Spring Harbor ...

STUART, Fla.--(BUSINESS WIRE)--Cognigenics, a pioneering company in RNA-based therapeutics for neuropsychiatric conditions and neurocognitive disorders, announced the publication of its latest ...

Using the shRNA collections of The RNAi Consortium (TRC), the MISSION LentiPlex Pooled shRNA Libraries enable genome-wide RNAi screening at the bench-top level in a powerful, pooled lentiviral format.

GBU provides clones from the TRC1 shRNA library for gene knockdown research purposes. These clones are available to research groups within the Biocenter Finland network. The and sequence are available ...

Sigma-Aldrich has announced the release of the MISSION™ TRC shRNA human and mouse libraries for RNA interference-based research. The collection now carries approximately 65,000 shRNA vector constructs ...

What is Short Hairpin RNA? RNA serves a wide variety of roles within a cell, carrying out catalytic, regulatory, structural and genetic transferal functions. A type of artificial RNA, called short ...