Immunotherapy using modified chimeric antigen receptor (CAR) T cells has improved survival rates for pediatric patients with relapsed and recurrent leukemia. However, these therapies are not as ...

Cytokines are key to immune regulation. Their extensive impact on human biology and disease has led to their long-term therapeutic use in treating cancer and a range of other diseases. Interleukin-2 ...

Current cell therapies like CAR-T cells lack the precision to distinguish between healthy and diseased tissue, leading to limited effectiveness and potential side effects. One of the most significant ...

Researchers from the Keck School of Medicine of USC have developed a new type of chimeric antigen receptor (CAR) T cell that ...

Psoriasis, a chronic inflammatory skin condition characterized by dry and scaly skin lesions, affects about 7.5 million people in the United States. Psoriasis results from abnormal proliferation of ...

Expression of cytokines or growth factors and their subsequent binding to cell surface receptors in healthy individuals is a tightly regulated and coordinated process. The inappropriate expression of ...

The B-cell cytokine BlyS/BAFF (B-cell activating factor; also referred to as TALL-1, THANK or zTNF4) plays a critical role in B-lymphocyte development. Two receptors for the tumor necrosis factor ...

Lang Rao, Shuai Xia, Wei Xu, Rui Tian, Guocan Yu, Chenjian Gu, Pan Pan, Qian-Fang Meng, Xia Cai, Di Qu, Lu Lu, Youhua Xie, Shibo Jiang, Xiaoyuan Chen Proceedings of the National Academy of Sciences of ...

Physicians have long observed a mystifying phenomenon: After a bout of infection or an autoimmune disease flare-up, some people experience prolonged mood swings, emotional dysregulation, and changes ...