Proteins that fold over free-energy barriers ≤ 3RT are classified as downhill folders. This regime is characterized by equilibrium unfolding that is proportionally broader and more complex the lower ...

In this paper, we present a framework for studying folding problems from a motion-planning perspective. The version of the motion-planning problem we consider is that of determining a sequence of ...

Predicting how a protein folds based solely on its amino acid sequence is an ongoing challenge for the fields of Bioinformatics and Computer Science. Previous attempts to solve this problem have ...

Coarse-grained molecular dynamics simulations offer a dramatic extension of the time-scale of simulations compared to all-atom approaches. In this article, we describe the use of the physics-based ...

Recently published research identified the key COF elements that are integral to protein folding, and a one-step approach to modulate it. A team led by senior authors Yao Chen, PhD, professor ...