Landmark concert venues, museums, and music trails around the South continue to tell the region’s ever-changing sonic story.

Little Five Points Diner, freshly painted a high-energy yellow, is nestled in a curve where a residential street dead-ends and hipster revelry begins—or, more literally, Moreland and Euclid avenues.

A local radio host and owner of Reel Animals Fishing Charters, he explains why this area is so special, “People don’t always ...