Cancer immunotherapy has saved lives, but it often falls short due to off-target toxicity and weak tumor-specific immune ...

Princeton researchers have resolved a decades-old mystery in cancer biology: vitamin A both fuels and undermines the immune ...

A new Phase I clinical trial provides proof of concept for a potential therapy for treatment-resistant cancers, particularly ...

Ultimately, Dr. Minn notes, success in immuno-oncology will be measured in multiple ways: Scientifically, by the depth of ...

It sits behind the breastbone, just above and in front of the heart. By middle age, it largely turns to fat, often even ...

Immune checkpoint inhibition disrupts receptor–ligand checkpoint signaling that restrains immunity, thereby enabling T-cell–mediated cancer-cell killing while increasing risk of autoimmune-like ...

After nearly 100 years of development, treatments that bolster the body's immune system to fight cancer are coming of age – and saving patients' lives.

Non-small cell lung cancer (NSCLC) is a leading global cause of cancer-related death, and immune checkpoint inhibitors (ICIs) have revolutionized its treatment by reactivating the immune system to ...

Objective Immune checkpoint inhibitors (ICIs) have revolutionised cancer treatment and patients’ survival. However, ICIs also cause severe immune-related adverse events, notably colitis, resulting in ...

Experts at Cincinnati Children's report proof-of-concept results that may sharply reduce the risk of a lethal side effect that has negatively impacted the use of revolutionary cancer immunotherapies ...

When immune checkpoint inhibitors are used in cancer treatment, in some cases it can lead to severe inflammation and damage to heart tissue. Histology images of mouse heart tissue illustrate the ...