Mikey Madison won Best Actress for 'The Substance' at the Oscars 2025, beating Cynthia Erivo, Karla Sofía Gascón, Demi Moore and Fernanda Torres.

After Demi Moore lost the best actress Oscar to a younger star, Mikey Madison, fans of "The Substance" couldn't help but point out the irony.

Mikey Madison, at 25, is the ninth-youngest best actress winner. Sean Baker is the first person to win four Oscars for the same movie: He produced, directed, wrote and edited it, winning statues for every hat he wore.

Mikey Madison won the best actress Oscar on Sunday for “Anora,” a role that catapulted the 25-year-old into a burgeoning film career after achieving initial success on television. The Brooklyn-set comedy-drama had received six nominations.

Mikey Madison took home the trophy for best actress at the 97th Academy Awards – a bit of a shock to viewers at home counting on Demi Moore.

Mikey Madison, 25, shocked the audience by becoming one of the youngest best actress winners in Academy history, over presumed front-runner Demi Moore.

Moore had been considered a favorite for her strong performance in “The Substance,” but Madison won for “Anora.”