In 1987, sudden and intense rainfall caused the river to surge at an unprecedented rate in mid-July, leading to a tragedy that killed 10 campers at Pot O' Gold Christian Camp, a summer camp near Comfort, Texas. The campers drowned when their bus attempted to evacuate them and was overtaken by floodwater.

Eyewitness Tonia Fucci recounted the destruction that followed deadly floods in Comfort, central Texas, near the Guadalupe River on July 4.