Background All lung cancer CT screening trials used fixed follow-up intervals, which may not be optimal. We developed new lung cancer risk models for personalising screening intervals to 1 year or 2 ...

Background Alveolar macrophages (AM) in COPD have fundamentally impaired responsiveness to Toll-like receptor 2 (TLR2) and TLR4 ligands of non-typeable Haemophilus influenzae (NTHI). However, the ...

Background and objectives IgG4-related disease (IgG4-RD) is a multi-system fibro-inflammatory disorder originally described in association with autoimmune pancreatitis (AIP), usually but not always in ...

Introduction We delivered a one-year weight management programme (Counterweight Plus, CWP) in participants with difficult-to-treat asthma and obesity in a single-centre randomised controlled trial ...

Introduction Despite improvements in pulmonary function, physical activity (PA) levels remain significantly lower than the general population, even at 1 year following lung transplantation (LTx).

Background This study reports preliminary outcomes from a joint Respiratory Consultant and Speech and Language Therapist (SLT) ‘one stop’ cough clinic. Local and tertiary referrals were accepted.

Rationale Chronic obstructive pulmonary disease (COPD) is associated with systemic inflammation and cardiovascular disease. Interaction between inflammatory cells and activated platelets is important ...

Rationale Despite high prevalence of e-cigarette use (vaping), little is currently known regarding the health effects of secondhand nicotine vape exposure. Objective To investigate whether exposure to ...

Introduction The benefits achieved during pulmonary rehabilitation (PR) are known to decline 6–12 months after the initial programme. There is no consensus on the best maintenance strategy.1 Previous ...

Method Adults with a first-recorded code for breathlessness (index date) and subsequent coded diagnosis between 2007 and 2017 were included from a UK primary care database (CPRD-GOLD). Cox regression ...

Introduction Better patient selection for non-invasive ventilation (NIV), and time to NIV initiation, are national improvement objectives.1Treatment escalation planning (TEP) was also identified ...

Introduction Chronic rhinosinusitis with nasal polyposis (CRSwNP) affects a significant proportion of people with severe asthma (SA). Despite the effectiveness of anti-IL5/5R therapies in the ...