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• All blood cells originate from hematopoietic stem cells in the bone marrow — a very common NCLEX concept. • Red Blood Cells (RBCs) contain hemoglobin for oxygen transport; lifespan 90–120 days. Low oxygen levels stimulate kidneys to release erythropoietin (EPO) → increases RBC production. • Neutrophils (55–70%) are the first line of defense in acute bacterial infection; lifespan 6–10 hours in circulation, 1–2 days in tissues. • Lymphocytes (T & B cells) mediate cell-mediated and humoral immuni
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