After years in neurosurgery, here’s my take. Ozempic, Wegovy, and Mounjaro (GLP-1–based medications) are not cosmetic drugs. They target metabolic disease — and metabolic disease directly impacts the brain. What high-quality trials show: • SELECT (NEJM, 2023): Semaglutide reduced major cardiovascular events in overweight/obese adults without diabetes. • SUSTAIN-6 (NEJM, 2016): Semaglutide reduced stroke risk in patients with type 2 diabetes. • SURPASS program (2021–2023): Tirzepatide produced su
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After years in neurosurgery, here’s my take. Ozempic, Wegovy, and Mounjaro (GLP-1–based medications) are not cosmetic drugs. They target metabolic disease — and metabolic disease directly impacts the brain. What high-quality trials show: • SELECT (NEJM, 2023): Semaglutide reduced major cardiovascular events in overweight/obese adults without diabetes. • SUSTAIN-6 (NEJM, 2016): Semaglutide reduced stroke risk in patients with type 2 diabetes. • SURPASS program (2021–2023): Tirzepatide produced su
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